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WebJul 1, 2003 · Introduction. Five years ago, it was estimated that 151 million people worldwide had diabetes mellitus, almost 97% of these cases being type 2 diabetes [].It is also recognized that an increasing number of patients reach end-stage renal disease (ESRD) due to diabetic nephropathy, which is the leading cause of ESRD [].The natural history … WebIntroduction. The incidence of diabetic kidney disease (DKD) has increased as the number of people with diabetes has increased, 1 and is the primary cause of end-stage nephropathy in China. 2 The renin-angiotensin-system is a crucial pathogenic factor in the development of DKD, and has long been considered as a therapeutic target. 3 Despite … WebApr 5, 2011 · The association of diabetes and hypertension has been known for a long time. 1 Joslin and colleagues 2 found that only 15% of diabetics between 25 and 50 years, yet 35% in patients older than 50 years, had systolic pressures >150 mm Hg, presumably as a result of delayed onset of diabetic nephropathy. With the prolongation of the lifespan, … high rise legging jeans